Evidence map›Paper›PMID 42695199›Full record

ArticleChemical communications (Cambridge, England)2026

Observation of hidden dynamics underlying facilitated dissociation of proteins from DNA.

Ridvan Nepravishta, Junji Iwahara

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ridvan NepravishtaDepartment of Biochemistry & Molecular Biology, Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555-1068, USA. j.iwahara@utmb.edu.ORCID http://orcid.org/0000-0002-0051-762X
Junji IwaharaDepartment of Biochemistry & Molecular Biology, Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555-1068, USA. j.iwahara@utmb.edu.ORCID http://orcid.org/0000-0003-4732-2173

Funding

Dynamics of DNA scanning and recognition by transcription factorsR35GM130326 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Junji Iwahara · 2019 to 2026
$4.2M
NIGMS NIH HHS R35 GM130326
6 · The paper itself

Abstract

Using NMR and stopped-flow fluorescence, this study reveals hidden dynamics of the transcription factor CREB bound to DNA. Before fully dissociating from DNA, CREB undergoes many cycles of microscopic dissociation and reassociation. The hidden rebinding dynamics allows competitor proteins to displace CREB efficiently, providing a mechanistic basis for facilitated dissociation.

Indexed as

Cyclic AMP Response Element-Binding ProteinDNAProtein BindingCyclic AMP Response Element-Binding ProteinDNA

Identifiers

PMID42695199
PMCPMC13589478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.