Evidence map›Paper›PMID 42695158›Full record

ArticleBasic & clinical pharmacology & toxicology2026

Effects of Trazodone on Testicular Morphology, Sperm Parameters and Contractility of the Distal Cauda Epididymal Duct in Rats.

Maria Santana da Silva, Vitória Barros Marques, Fernanda Karoline Oliveira da Silva, Maele Oliveira de Sena, Yanka do Vale Carvalho, Bruna da Silva Figueiredo, Luana Talinne da Costa Gomes, Samia Ellen Alves Fernandes, Edherlayne Bezerra Dos Santos Silva, Jackson Nazareno Gomes de Lima and 4 more

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In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Santana da SilvaMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Vitória Barros MarquesMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0009-0005-7069-5041
Fernanda Karoline Oliveira da SilvaMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Maele Oliveira de SenaMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Yanka do Vale CarvalhoMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0009-0005-7242-1570
Bruna da Silva FigueiredoMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Luana Talinne da Costa GomesMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Samia Ellen Alves FernandesMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Edherlayne Bezerra Dos Santos SilvaMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Jackson Nazareno Gomes de LimaMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0009-0007-4200-1545
Anna Karynna Alves de Alencar RochaMaurício de Nassau University Center, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0009-0001-9534-2980
Expedito Silva do Nascimento JuniorDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0000-0002-6218-9238
Elaine Cristina GavioliDepartment of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0000-0001-8967-1369
Edilson Dantas da Silva JuniorMode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.ORCID https://orcid.org/0000-0001-5505-8056

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) 00x0ma614Pro-Rectory of Research of Federal University of Rio Grande do Norte (Portuguese: Pro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte) 03/2018The Brazilian National Council for Scientific and Technological Development (Portuguese: Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq) 310880/2022-0
6 · The paper itself

Abstract

Trazodone is an antidepressant approved for the treatment of major depressive disorder and is associated with a low incidence of sexual dysfunction. However, its effects on male reproductive health are not yet fully understood. Therefore, this study aimed to evaluate the effects of repeated trazodone administration on reproductive parameters and the distal cauda epididymal duct contractions in rats. Adult male Wistar rats were orally treated by gavage for 21 days with saline (control) or trazodone at 10 and 20 mg/kg. After treatment, the blood and reproductive organs were collected for the experimental analysis. Trazodone induced adverse reproductive effects in rats, evidenced by testicular tissue damage, increased intratesticular lipid peroxidation and reduced sperm production and sperm count in different epididymal regions. Additionally, trazodone treatment reduced progressive sperm motility, the number of viable and morphologically normal sperm, indicating decreased sperm quality. The contraction of the isolated distal cauda epididymal duct was also impaired by trazodone treatment, suggesting possible alterations during the emission phase of ejaculation. In conclusion, trazodone exhibited significant reproductive effects that may impair male fertility. These findings provide, to our knowledge, the first integrated assessment of trazodone-induced changes in testicular morphology, sperm parameters and epididymal duct contractility.

Indexed as

Antidepressive Agents, Second-GenerationEpididymisSpermatozoaTestisTrazodoneAnimalsEjaculationFertilityLipid PeroxidationMaleMuscle ContractionRatsRats, WistarSperm CountSperm MotilityAntidepressive Agents, Second-GenerationTrazodoneepididymisratsreproductive parameterstestistrazodone

Identifiers

PMID42695158
PMCPMC13543052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.