Evidence map›Paper›PMID 42695041›Full record

ArticleInternational journal of biological sciences2026

Cross-tissue single-cell atlas reveals Id2 promotes sepsis-induced tissue damage by mediating macrophage metabolic reprogramming via Pkm2.

Xiaodan Wang, Yiyan Liu, Yuanqun Zhou, Liyong Zou, Xiaowei Zhou, Zhongyuan Du, Daiqin Bao, Yibo Zhao, Yu Zhu, Yue Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaodan WangDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yiyan LiuDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yuanqun ZhouDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Liyong ZouDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Xiaowei ZhouDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Zhongyuan DuDepartment of Anesthesiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Daiqin BaoDepartment of Anesthesiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yibo ZhaoCollege of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing, 400054, China.
Yu ZhuDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yue WuDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Xingnan OuyangDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Li WangDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Liangming LiuDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Tao LiDepartment of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As important immune cells, macrophage polarization is directly related to tissue damage in sepsis, and the polarization of macrophages is associated with their metabolic patterns. Previous studies exploring macrophage function in sepsis mainly focused on specific tissues, lacking comprehensive comparisons between tissues. Herein, we performed single-cell RNA sequencing (scRNA-seq) to systematically profile macrophages derived from the brain, heart, intestine, lung, spleen, and peripheral blood mononuclear cells (PBMCs) under homeostatic and septic conditions. Under steady-state, we detected the markers of macrophages in different tissues, classified the macrophages into 10 functional subtypes and compared the differences in their distribution among tissues. In sepsis, we found that

Indexed as

Inhibitor of Differentiation Protein 2MacrophagesMembrane ProteinsPyruvate KinaseSepsisThyroid HormonesAnimalsMaleMetabolic ReprogrammingMiceMice, Inbred C57BLThyroid Hormone-Binding ProteinsIdb2 protein, mouseInhibitor of Differentiation Protein 2Membrane ProteinsPkm protein, mousePyruvate KinaseThyroid Hormone-Binding ProteinsThyroid HormonesId2macrophagesmetabolic reprogrammingPkm2sepsis

Identifiers

PMID42695041
PMCPMC13540997

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.