ArticleCureus2026
Allopurinol-Induced Leukocytoclastic Vasculitis With Systemic Inflammatory Response: A Case Report From Azerbaijan.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Allopurinol is a commonly prescribed xanthine oxidase inhibitor used in the management of hyperuricemia and gout. Although generally well tolerated, it is associated with rare but potentially life-threatening hypersensitivity reactions, including allopurinol-induced vasculitis. We present the case of a 66-year-old woman who developed an acute cutaneous eruption 14 days after initiating allopurinol 100 mg daily for the management of recurrent gout. She subsequently developed systemic inflammatory manifestations, hepatic involvement, hematologic abnormalities, and immunologic activation consistent with drug-induced vasculitis following exposure to allopurinol. Laboratory findings demonstrated marked elevation of inflammatory markers, liver enzymes, immunoglobulin E levels, and evolving hematologic changes, including eosinophilia followed by lymphocytosis. The patient required plasmapheresis as part of management. This case highlights the importance of early recognition of drug-induced vasculitis and the need for prompt intervention to prevent progression to severe systemic complications.
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