ArticleAlpha psychiatry2026
Non-Suicidal Self-Injury in Adolescents With Major Depressive Disorder: The Role of Beta-Endorphin, Psychological Pain, and Anhedonia.
Article in Alpha psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: A substantial proportion of adolescents with major depressive disorder (MDD) engage in non-suicidal self-injury (NSSI); however, the biological and psychological factors differentiating those with and without NSSI remain poorly characterized. This study aimed to investigate whether serum beta-endorphin levels, psychological pain, and anhedonia differ between these groups and to explore their associations with the presence of NSSI. Methods: The study sample comprised adolescents prospectively recruited during the study period and diagnosed with MDD according to the Results: The study cohort consisted of 104 adolescents with MDD, including 52 participants in the NSSI+ group and 52 in the NSSI- group. The sample comprised 85 females (81.7%) and 19 males (18.3%). Compared with the NSSI- group, adolescents in the NSSI+ group demonstrated significantly lower serum beta-endorphin levels and significantly higher levels of depressive symptoms, psychological pain, and anhedonia (all Conclusions: These findings highlight the relevance of both psychological and neurobiological factors in NSSI among adolescents with MDD and suggest that an integrated assessment of these factors may help identify adolescents at increased risk of this form of self-harm.
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