Evidence map›Paper›PMID 42694879›Full record

ArticleInternational journal of medical sciences2026

CRISPR/Cas9-Driven

Chien-Wei Huang, Hsin-Hung Chen, Tzu-Ming Jao, Chia-Jung Li, Junne-Ming Sung, Yau-Sheng Tsai, Jin-Shuen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chien-Wei HuangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsin-Hung ChenDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Tzu-Ming JaoGlobal Innovation Joint Degree Program, International Joint Degree Master's Program in Agro-Biomedical Science in Food and Health, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-Jung LiDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Junne-Ming SungInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yau-Sheng TsaiInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jin-Shuen ChenDivision of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FNDC5 has been implicated in glucose homeostasis and is associated with mitochondrial function. Its role in diabetes and diabetic nephropathy (DN) remains unclear. This study hypothesizes that FNDC5 deficiency predisposes the kidney to accelerated mitochondrial dysfunction in diabetes and DN. Systemic

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesFibronectinsMitochondriaAnimalsCRISPR-Cas SystemsDiet, High-FatHumansKidneyLipid PeroxidationMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial DynamicsOxidative StressFibronectinsFNDC5 protein, mousePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseStreptozocindiabetic nephropathyFndc5irisinmitochondrial dynamicsmitochondrial morphologyoxidative stress

Identifiers

PMID42694879
PMCPMC13539912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.