ArticleFrontiers in toxicology2026
Dimethyl sulfoxide perturbs sleep-related behavioral organization in multiple species and confounds interpretation of sleep phenotypes.
Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Dimethyl sulfoxide (DMSO) is a very commonly used solvent in biological research and generally considered an inert experimental vehicle. However, DMSO can alter physiological functions, raising concerns regarding its effects on behavioral phenotypes. Such concerns may be particularly important in sleep research because sleep-related behaviors are highly sensitive to physiological perturbations. Methods: In this study, we systematically examined the effects of DMSO on sleep-related behaviors in Results: In Discussion: These findings demonstrate that DMSO is not merely a passive solvent in sleep research, but a biologically active perturbant, which is capable of confounding sleep-related behavioral phenotypes in both
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.