ReviewFrontiers in chemistry2026
Advances in galactose-based small-molecule hepatocyte-targeting probes for detecting biomarkers in hepatocellular carcinoma.
Review in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hepatocellular carcinoma (HCC) is a type of malignant tumor with a low early detection rate, high morbidity, and high mortality. Therefore, early diagnosis of HCC is essential for improving patient survival and treatment outcomes. Traditional diagnostic approaches generally exhibit insufficient specificity and sensitivity. However, small-molecule fluorescent probes offer advantages, such as non-invasiveness, high sensitivity, and real-time imaging capabilities, are considered ideal tools for liver cancer research, and are widely used in imaging and treatment studies. Asialoglycoprotein receptor (ASGPR) is overexpressed on hepatoma cells, and galactose can be recognized by ASGPR via the cluster glycoside effect; hence, various galactose-based small-molecule hepatocyte-targeting fluorescent probes have been developed. These probes can target hepatocytes via receptor-mediated endocytosis and release a fluorescent dye upon reactions with specific small molecules or enzymatic biomarkers, making them powerful tools for the early diagnosis of HCC. The present work is a review of recent advances in galactose-based small-molecule hepatocyte-targeting probes for detecting HCC-related markers and provides a detailed account of their physicochemical properties and applications in cellular and biological systems. We also conduct an in-depth examination of existing issues and provide a summary of the future trends and challenges. We hope that this review may promote the development of novel fluorescent probes for HCC detection and further provide meaningful guidance for the diagnosis and treatment of HCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.