Evidence map›Paper›PMID 42694789›Full record

ArticleInternational journal of biological sciences2026

DNAJB4 Protects Against Atherosclerosis by Stabilizing the HSP70-LXRα Axis in Hepatic Lipid Metabolism.

Wen-Hua Chen, Chia-Hui Chen, Man-Chen Hsu, Po-An Hu, Hsueh-Te Lee, Hsuan-Yun Hu, Kang-Yi Su, Wei-Lun Hsu, Tzong-Shyuan Lee

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Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen-Hua ChenGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Chia-Hui ChenGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Man-Chen HsuGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Po-An HuGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Hsueh-Te LeeInstitute of Anatomy & Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Hsuan-Yun HuInstitute of Anatomy & Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Kang-Yi SuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Wei-Lun HsuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Tzong-Shyuan LeeGraduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNAJB4, a member of the DNAJ/HSP40 family, functions as a co-chaperone of HSP70, regulating protein homeostasis and cellular functions. However, the molecular mechanism underlying the biological effect of DNAJB4 on lipid metabolism remains unclear. We investigated the role of DNAJB4 and its molecular mechanism in hyperlipidemia and atheroprone apolipoprotein E-null (

Indexed as

AtherosclerosisHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsLipid MetabolismLiverLiver X ReceptorsAnimalsApolipoproteins EMaleMiceMice, Inbred C57BLMice, KnockoutApolipoproteins EHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsLiver X ReceptorsNr1h3 protein, mouseatherosclerosisDNAJB4HSP40HSP70LXRα

Identifiers

PMID42694789
PMCPMC13541000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.