Evidence map›Paper›PMID 42694758›Full record

ArticleInternational journal of biological sciences2026

From Cysteamine to Pepstatin A: Targeting Cathepsin D To Improve Bone Health in Cystinosis.

Giulia Battafarano, Michela Rossi, Olivia Pagliarosi, Laura Di Giuseppe, Jacopo Di Gregorio, Sara Terreri, Cristiano De Stefanis, Marco Pezzullo, Gianna Di Giovamberardino, Pamela Vernocchi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Giulia BattafaranoBone Physiopathology Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Michela RossiBone Physiopathology Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Olivia PagliarosiBone Physiopathology Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Laura Di GiuseppeBone Physiopathology Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Jacopo Di GregorioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Sara TerreriBone Physiopathology Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Cristiano De StefanisResearch laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Marco PezzulloResearch laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Gianna Di GiovamberardinoResearch Biobank, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pamela VernocchiMicrobiome Unit, Management and Diagnostic Innovations & Clinical Pathways Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Valeria MarzanoMicrobiome Unit, Management and Diagnostic Innovations & Clinical Pathways Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Lorenza PutignaniUnit of Microbiology and Diagnostic Immunology, and Microbiome Unit, Management and Diagnostic Innovations & Clinical Pathways Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Jessica D'AmicoUnit of Muscular and Neurodegenerative Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Fiorella PiemonteUnit of Muscular and Neurodegenerative Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Anna TarantaRenal Diseases Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Francesco EmmaRenal Diseases Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Andrea Del FattoreBone Physiopathology Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nephropathic cystinosis is a rare genetic lysosomal storage disorder caused by

Indexed as

Cathepsin DCysteamineCystinosisPepstatinsAmino Acid Transport Systems, NeutralAnimalsCell DifferentiationHumansMiceMice, KnockoutOsteoblastsAmino Acid Transport Systems, NeutralCathepsin DCysteaminepepstatinPepstatinsbone phenotypeCathepsin DcysteamineCystinosisPepstatin ASipa1

Identifiers

PMID42694758
PMCPMC13540694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.