ReviewFrontiers in microbiology2026
FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease.
Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Intestinal fucosylation, the enzymatic addition of fucose to glycoconjugates, represents a pivotal regulatory mechanism that modulates host-microbiota crosstalk in the gastrointestinal tract. This review comprehensively synthesizes current advances in the molecular mechanisms, multilevel regulatory networks, and functional implications of intestinal mucosal fucosylation. This review focuses on α(1,2)-fucosylation catalyzed by fucosyltransferase 2 (FUT2)-a reaction that determines the secretor status and modifies critical glycoconjugates, including mucins and human milk oligosaccharides. This review examines the dynamic regulation of epithelial fucosylation by host-derived factors-including immune mediators [notably interleukin-22 (IL-22) secreted by group 3 innate lymphoid cells (ILC3s)], the enteric nervous system (ENS), and microbial signals. Furthermore, this review details how fucosylated glycans shape the gut microbial ecosystem by serving as selective nutrient sources for beneficial symbionts-including
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