ArticleFrontiers in pediatrics2026
Evaluation of regional differences, age, and sex variations in hematological parameters among adolescents in Sudan: a multicenter community-based cross-sectional study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Recently, greater attention has been paid to the influence of regional differences, age, and sex on hematological parameters, particularly among adolescents. No such data are available in Sudan. The current study aimed to investigate the associations between regional differences, age, sex, and hematological parameters [hemoglobin, white blood cell [WBC], red cell distribution width [RDW], and platelets] among adolescents in northern and eastern Sudan. Methods: A comparative community-based cross-sectional study was conducted in northern and eastern Sudan. The adolescents' sociodemographic data were collected via a questionnaire. The studied hematological parameters were measured using an automated hematology analyzer. Multiple linear regression analysis was performed. Results: A total of 738 adolescents participated in the study, comprising 356 from northern Sudan and 382 from eastern Sudan, with 44.0% males and 56.0% females. The median age was 14.8 years, and the hematological parameters were as follows: hemoglobin 12.9 g/dL, WBC 6.0 × 10 Conclusion: The study identified notable regional variations in hematological parameters among adolescents in Sudan, with northern Sudan showing higher hemoglobin and RDW levels, whereas eastern Sudan had increased WBC and platelet counts. Further research is recommended to establish age-, regional differences-, and gender-adjusted cutoff values for hematological parameters in clinical practice to improve the diagnosis and prognosis of hematological disorders among Sudanese adolescents.
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