ReviewAlpha psychiatry2026
Excitation/Inhibition Balance as a Mechanistic Link Between Sleep Disturbance and Autism Spectrum Disorder: A Bidirectional Framework.
Review in Alpha psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep disturbances are highly prevalent in autism spectrum disorder (ASD), yet their significance may extend beyond that of a common co-occurring condition. Growing evidence suggests that excitation/inhibition (E/I)-related network dysregulation may provide a valuable framework for understanding the association between sleep disturbances and variability in core ASD symptom expression. This review synthesizes findings from polysomnography, actigraphy, circadian rhythm research, neuroimaging, electrophysiological studies, and animal models to examine how E/I-related vulnerability in ASD may contribute to impaired sleep initiation and maintenance. It further explores how sleep and circadian disruption may, in turn, influence daytime symptom expression through alterations in synaptic homeostasis and network rebalancing. By proposing a bidirectional framework, this review aims to integrate current evidence on sleep-related symptom variability in ASD and to inform future longitudinal, mechanistic, and biomarker-driven research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.