Evidence map›Paper›PMID 42694482›Full record

ReviewFrontiers in cellular and infection microbiology2026

Design, processing, and modeling for longitudinal multiomics microbiome data.

Kaiyan Ma, Margaret Thairu, Kris Sankaran

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kaiyan MaChangping Laboratory, Beijing, China.
Margaret ThairuWisconsin Institute for Discovery, University of Wisconsin - Madison, Madison, WI, United States.
Kris SankaranWisconsin Institute for Discovery, University of Wisconsin - Madison, Madison, WI, United States.

Funding

DMS/NIGMS 1: Modeling Microbial Community Response to Invasion: A Multi-Omics and MultifactonR01GM152744 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HANDELSMAN, JO E., SANKARAN, KRIS · 2023 to 2025
$600k
NIGMS NIH HHS R01 GM152744
6 · The paper itself

Abstract

Longitudinal multiomics studies can reveal mechanisms underlying microbiome dynamics. Though gathering such data has become increasingly accessible, challenges remain in experimental design, data processing, and interaction modeling. This mini-review surveys practical approaches for analyzing longitudinal multiomics microbiome data. We provide an overview of fundamental questions these experimental designs can address, discuss concepts for reducing confounding, review tools for data management, and describe statistical and machine learning methods for identifying interactions across time and biological layers. We conclude with emerging trends and open problems.

Indexed as

MicrobiotaMultiomicsHumansLongitudinal StudiesMachine LearningResearch Designdata integrationinteraction modelinglongitudinal datamicrobiomemultiomicsnetworks

Identifiers

PMID42694482
PMCPMC13539529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.