ArticleSAGE open medicine2026
Bone turnover biomarkers and semi-quantitative bone histomorphometry in chronic kidney disease: Comparison between patients with and without fractures.
Article in SAGE open medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic kidney disease (CKD) is associated with increased fracture risk not fully explained by reduced bone mineral density. CKD-mineral and bone disorder (CKD-MBD), involving abnormalities in bone turnover, mineralization, and microarchitecture, contributes to skeletal fragility. However, the relationship between routine biochemical markers and semi-quantitative bone histomorphometry remains inadequately defined, particularly in resource-limited settings and the Indian population. The objective of this study was to compare biochemical markers and semi-quantitative bone histomorphometric findings in CKD patients with and without fractures. Methods: In this hospital-based comparative cross-sectional study, 48 patients with CKD stage 3-4 were divided into fracture (n = 24) and non-fracture groups (n = 24). Serum calcium, 25-hydroxyvitamin D, parathyroid hormone (PTH), and alkaline phosphatase (ALP) were measured. Bone samples were obtained intraoperatively or via transiliac crest biopsy. Semi-quantitative bone histomorphometry was assessed by a pathologist. Statistical analysis included appropriate group comparisons. Results: Fracture patients had significantly lower vitamin D (p = 0.007) and calcium (p = 0.005), and higher PTH (p = 0.002) and ALP (p = 0.001). Semi-quantitative histomorphometric evaluation showed increased osteoid volume, reduced trabecular thickness, and elevated osteoblastic and osteoclastic activity. Conclusion: In our study cohort, CKD patients with fractures exhibited a high-turnover bone phenotype with increased osteoid volume and altered bone histology. Biochemical markers may serve as cost-effective adjuncts for fracture risk stratification, particularly where advanced diagnostics are limited. Findings should be interpreted cautiously given the cross-sectional design and small sample size.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.