Evidence map›Paper›PMID 42694373›Full record

ReviewFrontiers in pharmacology2026

Fighting the invader: strategies against intracellular bacteria.

Blanca Lorente-Torres, Pablo Castañera, Jesús Llano-Verdeja, Helena Á Ferrero, Sergio Fernández-Martínez, Farzaneh Javadimarand, Luis M Mateos, Álvaro Mourenza, Michal Letek

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Blanca Lorente-TorresDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Pablo CastañeraDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Jesús Llano-VerdejaDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Helena Á FerreroDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Sergio Fernández-MartínezDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Farzaneh JavadimarandDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Luis M MateosDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.
Álvaro MourenzaInstituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain.
Michal LetekDepartamento de Biología Molecular, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, León, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular pathogenic bacteria are often-overlooked agent of chronic, recurrent and difficult-to-treat infections in a context of escalating antimicrobial resistance. By hiding within professional and non-professional phagocytes, adopting dormant or slow-replicative states and rewiring host pathways, these pathogens successfully evade both immune clearance and conventional antibiotic therapy, thus contributing to treatment failure and, potentially, carcinogenesis. Here we synthesise how obligate and facultative intracellular bacteria invade and persist within host cells, and interpret these processes as interconnected, engineerable modules of the host-pathogen interplay. Using

Indexed as

antimicrobial resistanceengineered anti-infective strategieshost–pathogen interplayintracellular persistenceintracellular reservoirs

Identifiers

PMID42694373
PMCPMC13539124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.