Evidence map›Paper›PMID 42694372›Full record

ArticleFrontiers in neuroscience2026

Whole-mount optical clearing of rabbit tenuissimus muscle for assessment of muscle spindle morphology.

Emily J Reedich, Brendan C Moline, Oluwatobi S Opesade, Cassandra Kramer, Jess E Glennon, Eden Fraatz, Katharina A Quinlan, Marin Manuel

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Emily J ReedichGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Brendan C MolineGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Oluwatobi S OpesadeGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Cassandra KramerGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Jess E GlennonGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Eden FraatzGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Katharina A QuinlanGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.
Marin ManuelGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, United States.

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Christopher Lee Hemme · 2012 to 2026
$63.6M
Validation of Prenatal Rabbit Hypoxia Ischemia as a Model of Cerebral Palsy-induced PainRF1NS135580 · NINDS · UNIVERSITY OF RHODE ISLAND · PI MEGAN R DETLOFF, Katharina Ann Quinlan · 2023 to 2026
$4.6M
Impairment of Spinal Development in Cerebral PalsyR01NS104436 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2017 to 2026
$4.3M
Serotonin Based Therapeutics in Cerebral PalsyR01NS132728 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2023 to 2026
$2.5M
NIGMS NIH HHS P20 GM103430NINDS NIH HHS R01 NS104436NINDS NIH HHS R01 NS132728NINDS NIH HHS RF1 NS135580
6 · The paper itself

Abstract

Muscle spindles are essential proprioceptive receptors that provide the sensory foundation for posture, movement coordination, and reflex control. However, their location deep inside muscles and complex three-dimensional architecture have historically limited morphological analysis to labor-intensive techniques such as silver-impregnation, muscle teasing, or serial sectioning followed by volumetric reconstruction. Here, we present a whole-mount optical clearing and multiplex fluorescence imaging workflow that enables

Indexed as

annulospiral endingiDISCOneuromuscular junctionperipheral nervous systemprimary afferentproprioceptionα-bungarotoxin

Identifiers

PMID42694372
PMCPMC13538837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.