ArticleFrontiers in aging2026
Collagen-induced restructuring of astrocytes and vessels in organotypic mouse brain slices.
Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The brain exhibits high plasticity and responds to many forms of external stimuli, such as trauma, seizures, drugs, and biomaterials. Collagen is a non-toxic biocompatible protein that participates in the plastic reformation of the brain. In this study, we explored whether collagen can reconstruct astrocytes and brain vessels by using microcontact printing on organotypic mouse brain slices. Methods: Organotypic brain slices from postnatal days 8-10 were prepared and connected to collagen microcontact prints. After 2-6 weeks, glial fibrillary acidic protein-positive (GFAP Results: Our data show that (1) collagen restructures laminin Discussion: Collagen has the distinctive potential to induce plasticity and the restructuring of vessels and astrocytes, however, collagen may also lead to cell death under certain conditions.
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