ArticleFrontiers in microbiology2026
Association between physical activity level and gut microbiota profiles in individuals with subthreshold depression: a cross-sectional study.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Subthreshold depression (SD) represents a subclinical state between mental health and major depressive disorder (MDD) and is associated with a high prevalence and substantial risk of progression to MDD. Physical activity (PA) has been proposed to exert antidepressant effects through modulation of the gut-brain axis. However, the association between PA level and gut microbiota profiles in individuals with SD remains poorly understood. Methods: This is a cross-sectional observational study. Stratified random sampling was used to screen full-time undergraduates aged 18-25 years at Jimei University for subthreshold depression. Following initial screening with the CES-D and secondary screening with a structured clinical interview, the HAMD-17, and the BDI-II, 122 participants were enrolled. Participants were assigned by IPAQ short form to low ( Results: No significant differences in α-diversity or β-diversity were observed among the three PA groups ( Conclusion: Although PA level was not significantly associated with overall gut microbial diversity in college students with SD, it was closely associated with the differential distribution of specific functional genera. These findings provide novel evidence supporting the role of PA-related microbial remodeling in SD and may facilitate the development of microbiota-targeted interventions that mimic exercise-induced benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.