Evidence map›Paper›PMID 42694256›Full record

ArticleNPJ dementia2026

Matrix and intermembrane space-specific mitochondrial stress response in Alzheimer's disease.

Shatakshi Shukla, Devin Kolmetzky, Shanikumar Goyani, Kunal Samantaray, Anupriya Sinha, Philip A Kramer, Dhanendra Tomar, Pooja Jadiya

Abstract read
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shatakshi ShuklaDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Devin KolmetzkyDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Shanikumar GoyaniDepartment of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Kunal SamantarayDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Anupriya SinhaDepartment of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Philip A KramerDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Dhanendra TomarDepartment of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.
Pooja JadiyaDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
Mitochondrial calcium uptake in Alzheimer's disease. Admin SupplementR00AG065445 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JADIYA, POOJA · 2022 to 2024
$845k
NIA NIH HHS P30 AG021332NIA NIH HHS R00 AG065445
6 · The paper itself

Abstract

Alzheimer's disease (AD) lacks effective therapies, partly due to an incomplete understanding of mitochondrial dysfunction, a key driver of neurodegeneration. Mitochondria activate the unfolded protein response (UPR

Indexed as

Cell biologyMolecular biologyNeuroscience

Identifiers

PMID42694256
PMCPMC13538033

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.