ArticleFrontiers in neuroscience2026
High-intensity interval exercise affects neurogenesis and angiogenesis differently in diabetic and non-diabetic mice.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Exercise and metabolic health are key modulators of brain plasticity, influencing processes such as angiogenesis and neurogenesis. Methods: The present study investigated the effects of eight weeks of high-intensity interval training on capillary density and neurogenesis in the hippocampus of diabetic ( Results: We show that exercise significantly enhanced capillary density in the dentate hilus of diabetic mice, while having no effect in non-diabetic mice. Conversely, neurogenesis in the subgranular zone was increased by exercise in non-diabetic mice but remained unaffected in their diabetic littermates. Furthermore, correlation analyses challenge the dogma that angiogenesis directly promotes neurogenesis. We found no effect of either exercise or genotype on capillary density in the stratum radiatum or neurogenesis in the ventricular-subventricular zone, indicating a regional specificity of these processes. Discussion: These findings challenge and nuance established concepts of cerebral angiogenesis and adult neurogenesis, and their regulation in response to T2D and physical exercise Understanding these differential responses to exercise provides new insights into cerebral effects of diabetes and may lay the foundation for tailoring interventions to optimize brain health in individuals with metabolic disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.