Peripheral γδ T-cell remodeling in psoriasis is associated with effector-biased transcriptional organization and reduced representation of a circulating

Background: Despite the prominent immune dysregulation in psoriasis, the organization of peripheral blood γδ T cell states remains incompletely defined. Methods: Here, we performed single-cell transcriptomic profiling of enriched peripheral blood-derived γδ T cells from healthy donors and patients with psoriasis. By integrating state annotation, inferred transcriptional ordering, ligand-receptor communication, transcriptome-inferred metabolite-sensor communication, and regulatory network analyses, we constructed a circulating γδ T-cell state atlas. Results: We identified eight γδ T-cell states. Within the resolution of this dataset, psoriasis-derived cells did not form a clearly separated disease-exclusive state; instead, disease-associated changes were mainly reflected by altered representation and transcriptional organization of pre-existing states, including reduced peripheral representation of a Conclusions: These findings support a state-resolved framework of circulating γδ T-cell remodeling in psoriasis and identify reduction and possible redistribution of a