ReviewNPJ dementia2026
Sleep and stress as modifiable drivers of Alzheimer's disease.
Review in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
Proper sleep and stress maintenance are essential for health and may contribute to disease progression when dysregulated. This review highlights the intricate links between sleep, stress, and Alzheimer's disease, including underlying neural circuitry and mechanisms that contribute to disease. Sleep is essential for protein clearance pathways including autophagy and the glymphatic system, which are impaired in neurodegenerative diseases. Similarly, chronic stress incites neuroinflammatory responses known to be elevated in brains of patients with neurodegeneration. As a result, it is perhaps unsurprising that tau pathology and neurodegeneration affect sleep and stress circuitry in the brain, including the Locus Coeruleus and Lateral Hypothalamus, beginning in prodromal phases of Alzheimer's disease. Though the precise mechanisms underscoring these vulnerabilities are incompletely understood, this provides a unique therapeutic opportunity for targeting these pathways in early Alzheimer's disease patients with concomitant sleep impairments and/or chronic stress. In this review, we offer insights into these relationships including specific brain region involvements, the contribution of molecular mechanisms of disease, and these translational opportunities which may arise.
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