ArticleParasites & vectors2026
Evaluation of the trūRapid
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeartworm disease, caused by Dirofilaria immitis, is a globally distributed and clinically significant cardiopulmonary condition affecting dogs and other animal species. Dogs typically lack overt clinical signs in the early stages of infection, and disease progression can lead to worsening clinical signs and poor prognosis. The purpose of this study was to evaluate the performance of the tr?Rapid™ FOUR heartworm antigen test (Antech Diagnostics) for the detection of D. immitis antigen in canine serum samples and to compare its performance with another commercially available point of care (POC) heartworm antigen test, specifically the SNAP® 4DX® Plus (IDEXX), using DiroCHEK® (Zoetis) as the reference test.
methodsA total of 350 canine remnant serum samples were evaluated using tr?Rapid™ FOUR, SNAP® 4DX® Plus, and DiroCHEK® as per manufacturers' instructions.
resultsFor samples positive at DiroCHEK® (n = 149), the sensitivity of the tr?Rapid™ FOUR heartworm antigen test was 98.7% (95% CI 94.3-99.6%), with a specificity of 100% (95% CI 98.2-100%) for samples negative at DiroCHEK® (n = 201). The tr?Rapid™ FOUR showed excellent agreement with another available POC test, the SNAP® 4DX® Plus (0.994 ? agreement, 95% CI 0.983-1.000).
conclusionsThe findings demonstrate that the tr?Rapid™ FOUR heartworm antigen test provides reliable diagnostic accuracy, ease of use, and a fast time to result (10 min), making it a robust POC option for detecting canine heartworm infection. Its performance is comparable to the reference laboratory ELISA test, DiroCHEK®, and another commercially available POC test, SNAP® 4DX® Plus. Overall, the results support the use of the tr?Rapid™ FOUR heartworm antigen test as a dependable clinical tool for the detection and management of heartworm infection in dogs.
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