Evidence map›Paper›PMID 42693471›Full record

Trial reportCritical care (London, England)2026

Extracorporeal CO

Christian Karagiannidis, Jordi Riera, Pablo Blanco-Schweizer, Stephan Strassmann, Michaela Merten, Daniel Brodie, Thomas Staudinger, Wolfram Windisch, Laurent Brochard, Arthur S Slutsky

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christian KaragiannidisARDS and ECMO Centre Cologne-Merheim, University Witten/Herdecke, Ostmerheimer Str.200, 51109, Cologne, Germany. christian.karagiannidis@uni-wh.de.
Jordi RieraCritical Care Department, Vall d'Hebron University Hospital, SODIR, Vall d'Hebron Research Institute, Barcelona, Spain.
Pablo Blanco-SchweizerIntensive Care Unit, Rio Hortega University Hospital, Valladolid, Spain.
Stephan StrassmannARDS and ECMO Centre Cologne-Merheim, University Witten/Herdecke, Ostmerheimer Str.200, 51109, Cologne, Germany.
Michaela MertenARDS and ECMO Centre Cologne-Merheim, University Witten/Herdecke, Ostmerheimer Str.200, 51109, Cologne, Germany.
Daniel BrodieDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thomas StaudingerDepartment of Medicine I, Medical University of Vienna, Intensive Care Unit 13i2, Währinger Gürtel 18-20, Vienna, 1090, Austria.
Wolfram WindischARDS and ECMO Centre Cologne-Merheim, University Witten/Herdecke, Ostmerheimer Str.200, 51109, Cologne, Germany.
Laurent Brochard *Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Arthur S Slutsky *Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAcute exacerbations of chronic obstructive pulmonary disease (AE-COPD) requiring invasive mechanical ventilation (IMV) are associated with high mortality and long-term disability. Extracorporeal CO₂ removal (ECCO₂R) using modern high-capacity devices may facilitate early endotracheal extubation and reduce IMV-related complications.

objectivesTo evaluate whether ECCO

methodsAdults with acute hypercapnic respiratory failure due to AE-COPD requiring IMV who failed or were ineligible for extubation within 24 hours of intubation were randomized to ECCO

results18 patients were randomized before the trial was terminated early by the sponsor for financial reasons (planned enrollment: 192). The primary composite endpoint occurred in 0/8 ECCO

conclusionsIn this prematurely terminated trial, ECCO₂R-facilitated early extubation using a device with a capacity to eliminate more than 50% of the average CO

Indexed as

Carbon DioxidePulmonary Disease, Chronic ObstructiveRespiration, ArtificialSeverity of Illness IndexAgedFemaleHumansMaleMiddle AgedTreatment OutcomeCarbon DioxideCOPDECMOExacerbationNIVVentilation

Identifiers

PMID42693471
PMCPMC13543343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.