ArticleBiomolecular NMR assignments2026
The
Hoang H Dinh, Angela M Jasper, Antoine Baudin, Patrick Sung, David S Libich
Abstract read
In one paragraphArticle in Biomolecular NMR assignments, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Hoang H DinhDepartment of Biochemistry and Structural Biology, and Greehey Children's Cancer Research Institute, The University of Texas at San Antonio Health Science Center, 8403 Floyd Curl Dr., San Antonio, TX, 78229, USA.
Angela M JasperDepartment of Biochemistry and Structural Biology, and Greehey Children's Cancer Research Institute, The University of Texas at San Antonio Health Science Center, 8403 Floyd Curl Dr., San Antonio, TX, 78229, USA.
Antoine BaudinDepartment of Biochemistry and Structural Biology, and Greehey Children's Cancer Research Institute, The University of Texas at San Antonio Health Science Center, 8403 Floyd Curl Dr., San Antonio, TX, 78229, USA.
Patrick SungDepartment of Biochemistry and Structural Biology, and Greehey Children's Cancer Research Institute, The University of Texas at San Antonio Health Science Center, 8403 Floyd Curl Dr., San Antonio, TX, 78229, USA.
David S LibichDepartment of Biochemistry and Structural Biology, and Greehey Children's Cancer Research Institute, The University of Texas at San Antonio Health Science Center, 8403 Floyd Curl Dr., San Antonio, TX, 78229, USA. libich@uthscsa.edu.ORCID https://orcid.org/0000-0001-6492-2803 Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MRegulation of BRCA-dependent Genome Repair via the 53BP1 AxisP01CA275717 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAVID STEVEN LIBICH · 2024 to 2026
$10.1MYEAST DNA REPAIR GENES AND PROTEINS OF THE RAD52 GROUPR01ES007061 · NIEHS · YALE UNIVERSITY · PI Patrick Sung · 1995 to 2026
$9.4MMechanistic Dissection of the Fanconi Anemia Pathway of DNA Damage Response and RR01CA168635 · NCI · YALE UNIVERSITY · PI Gary M Kupfer, Patrick Sung · 2013 to 2026
$5.8MSouth Texas Medical Scientist Training Program (STX-MSTP)T32GM145432 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jose E Cavazos, Ratna K Vadlamudi · 2023 to 2026
$2.3MAn Integrated Biochemical and Structural Approach to Delineating the Biology of EWSR1 - Multi-Mode Detection and Imaging of Biomolecular Condensates.R01GM140127 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LIBICH, DAVID STEVEN · 2021 to 2025
$1.8MProtein Intrinsic Disorder in Genome RegulationR35GM163922 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAVID STEVEN LIBICH · 2026 to 2026
$378kThe Mechanistic Role of BRCA1-BARD1 DNA and RAD51 Binding in DNA Double-Strand Break RepairF30CA278370 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Angela Mary Jasper · 2023 to 2026
$172kNCI NIH HHS F30 CA278370NCI NIH HHS P01 CA275717NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA168635NIEHS NIH HHS R01 ES007061NIGMS NIH HHS R01 GM140127NIGMS NIH HHS R35 GM163922NIGMS NIH HHS T32 GM145432NIH HHS F30 CA278370, T32 GM145432NIH HHS R01 ES007061, R01 CA168635, P01 CA275717NIH HHS R01 GM140127, R35 GM163922, P01 CA275717Welch Foundation AQ-0012Welch Foundation AQ-2001-20190330
6 · The paper itselfAbstract
The tumor suppressor protein breast cancer type 1 susceptibility protein (BRCA1) plays a central role in maintaining genome stability through its involvement in DNA damage repair, transcriptional regulation, and cell-cycle control. BRCA1 functions as an obligate heterodimer with its binding partner, the BRCA1-associated RING domain protein 1 (BARD1), to coordinate accurate DNA repair. While the structured N- and C-terminal domains of BRCA1 have been well-characterized, the large central region encoded largely by exon 11 that comprises ~ 80% of the protein, is intrinsically disordered, and remains poorly structurally characterized. This intrinsically disordered region (IDR) harbors critical interaction interfaces for key proteins involved in genome maintenance, including RAD50, RAD51, MYC, and RB. Here, we report the backbone resonance assignments of a BRCA1 IDR construct spanning residues 467-696, providing a foundation for future studies aimed at understanding how the disordered central region of BRCA1 contributes to homologous recombination, interactions with BARD1, and overall BRCA1 tumor suppressor function.
Indexed as
BRCA1 ProteinIntrinsically Disordered ProteinsNuclear Magnetic Resonance, BiomolecularHumansProtein Structure, SecondaryBRCA1 ProteinIntrinsically Disordered ProteinsBARD1BRCA1DNA repairHomologous recombinationIntrinsically disordered proteinNMR
Identifiers
PMID42693354
PMCPMC13541922
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