Evidence map›Paper›PMID 42693325›Full record

ArticleCardiovascular engineering and technology2026

Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve Model.

Mads V Ancker, Sam E Stephens, Justin T Jack, Neil B Ingels, Jonathan F Wenk, Søren N Skov, Surendra K Chawla, Ajit P Yoganathan, Morten O Jensen

Abstract read
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Article in Cardiovascular engineering and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mads V AnckerDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.ORCID http://orcid.org/0009-0002-1938-7770
Sam E StephensDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.ORCID http://orcid.org/0000-0002-2312-9523
Justin T JackDepartment of Mechanical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.ORCID http://orcid.org/0000-0002-2486-9865
Neil B IngelsDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.ORCID http://orcid.org/0009-0001-6180-610X
Jonathan F WenkDepartment of Mechanical and Aerospace Engineering, University of Kentucky, Lexington, Kentucky, USA.ORCID http://orcid.org/0000-0003-0272-9914
Søren N SkovDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2352-853X
Surendra K ChawlaDivision of Cardiothoracic Surgery, Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA.
Ajit P YoganathanDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Morten O JensenDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA. mojensen@uark.edu.ORCID http://orcid.org/0000-0002-1607-6179

Funding

NHLBI NIH HHS 1R15HL177711-01NIH HHS 1R15HL145585-01
6 · The paper itself

Abstract

introductionThis study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correlation with the transvalvular pressure. MATERIALS AND

methodsPorcine (n = 10) and human (n = 4) mitral valves were mounted in a saddle-shaped annulus clamp, while an in vitro system was utilized to replicate a physiological systolic blood pressure by vacuum pressure applied to the atrial side of the valve. A Millar pressure catheter and force transducers ("C-gauges") were used to acquire the data. Strut chordal force was recorded simultaneously with the marginal chordal force, to serve as a verification of the employed equipment.

resultsThe marginal chordal force in porcine and human averaged to 0.012 N ± 0.008 N and 0.006 N ± 0.008 N respectively at peak systolic pressure of 120 mmHg. Additionally, a simplified finite element study was conducted and supports low marginal forces relative to intermediary chords. DISCUSSION &

conclusionThis low force calls into question the traditionally-described role of the marginal chordae in preventing mitral prolapse at closure. The chords do, however, still show signs of assisting with the leaflets' positioning. The relationship between marginal chordal forces and transvalvular pressure varies significantly across experiments, further obfuscating their role in normal valvular function.

Indexed as

Chordae tendineaeChordal forcesIn vitroMarginal chordaeMitral valvePapillary muscles

Identifiers

PMID42693325

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.