Evidence map›Paper›PMID 42693235›Full record

ArticleInternational ophthalmology2026

Graft outcomes, reinterventions, and macular morbidity after DMEK in vitrectomized versus non-vitrectomized eyes.

Dilara Altun, Emine Esra Karaca, Mehmet Önen, Öznur Bekmez, Özlem Evren Kemer

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dilara AltunDepartment of Ophthalmology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye. drdilara.altun@gmail.com.ORCID http://orcid.org/0009-0003-8249-5800
Emine Esra KaracaDepartment of Ophthalmology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.ORCID http://orcid.org/0000-0001-7124-4174
Mehmet ÖnenDepartment of Ophthalmology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.ORCID http://orcid.org/0000-0001-8797-9634
Öznur BekmezDepartment of Ophthalmology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.ORCID http://orcid.org/0009-0001-8717-7372
Özlem Evren KemerDepartment of Ophthalmology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.ORCID http://orcid.org/0000-0001-9480-8470

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare visual, anatomic, and graft-related outcomes after Descemet membrane endothelial keratoplasty (DMEK) in vitrectomized versus non-vitrectomized eyes, and to identify factors associated with adverse outcomes in these eyes.

methodsThis retrospective study analyzed DMEK performed between January 2018 and January 2025. Fifty-four vitrectomized eyes with pseudophakic bullous keratopathy (PBK) were compared with 50 non-vitrectomized PBK controls without major ocular comorbidity. Outcomes included best-corrected visual acuity (BCVA), central corneal thickness (CCT), endothelial cell density (ECD) and ECD loss, graft-related reinterventions, and cystoid macular edema (CME).

results104 eyes were analyzed. BCVA and CCT improved significantly in both groups (p < 0.001). At 12 months, vitrectomized eyes had lower ECD (1458 ± 545 vs 1759 ± 436 cells/mm

conclusionDMEK provides meaningful visual and anatomic improvement in vitrectomized eyes. However, versus controls they had greater endothelial cell loss, more frequent repeat DMEK, and markedly higher CME, whereas rebubbling and penetrating keratoplasty differences were nonsignificant. Given their heterogeneity, frequent capsular-zonular compromise, and the retrospective design, these associations warrant caution. Vitrectomized eyes represent a complex, higher-risk DMEK group warranting closer follow-up and individualized perioperative management.

Indexed as

Corneal DiseasesDescemet Stripping Endothelial KeratoplastyPostoperative ComplicationsVisual AcuityVitrectomyAgedCell CountEndothelium, CornealFemaleFollow-Up StudiesGraft SurvivalHumansMacular EdemaMaleMiddle AgedReoperationCystoid macular edemaDescemet membrane endothelial keratoplastyEndothelial cell densityGraft survivalPseudophakic bullous keratopathyVitrectomized eyes

Identifiers

PMID42693235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.