ArticleScientific reports2026
Quantification of intervertebral disc degeneration using dual-energy computed tomography collagen maps: a comparative study with MRI Pfirrmann grading.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
To determine the correlation between quantitative HU values derived from DECT collagen maps and the MRI-based Pfirrmann grade. We retrospectively reviewed IVDs in patients who underwent both spinal DECT and MRI within one year. CT scans were acquired using single-source DECT at 80 and 135-kVp with automatic exposure control. Three readers scored IVDs according to Pfirrmann et al. on T2-weighted MRI images. Quantitative evaluation involved placing three standardized regions of interest in each IVD in DECT-based cMaps; in corresponding 135-kVp DECT scans and MRI images. Mean density measurements of AF and NP were compared with PF-grades using linear mixed model analysis. We included 339 IVDs of 97 patients [mean age 59.1 years]; (53 women [mean age 63.5 years] and 44 men [mean age 53.8 years]). cMap analysis revealed a significant difference of AF and NP collagen and chondroitin density between PF-grade I and V(AF: MD = - 31.1HU (95% CI - 59.5 to - 2.7), p = 0.032;NP:MD = - 37.8HU (95% CI - 73.6 to - 2.0), p = 0.038). 135-kVp DECT showed no IVD density reduction corresponding to PF-grades. MRI showed significant reduction of signal intensities in AF and NP with increasing PF-grades. IVD collagen and chondroitin density declined with increasing PF-grade in DECT-based cMaps, suggesting DECT-based cMaps as an additional tool for IVD classification.
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