ArticleInternational ophthalmology2026
Short- and long-term impact of silicone hydrogel contact lens wear on the ocular surface and anterior segment: a confocal microscopy study.
Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate short- and long-term effects of silicone hydrogel contact lens (SHCL) wear on the ocular surface and anterior segment, with a particular focus on corneal subbasal nerve morphology and corneal sensitivity using in vivo confocal microscopy (IVCM).
methodsThirty eyes of 30 male participants without previous CL use were prospectively evaluated. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer's test, corneal sensitivity, and tear meniscus area (TMA) were measured at baseline, 1 month, and 1 year. Corneal subbasal nerve parameters and dendritic cell density were assessed by IVCM.
resultsOSDI scores increased significantly after 1 month of SHCL wear (9.8 ± 2.34 vs. 16.6 ± 3.34; p < 0.001), accompanied by a significant rise in dendritic cell density (14.65 vs. 29.75 cells/mm
conclusionShort-term SHCL wear was associated with transient ocular surface inflammation and discomfort, whereas long-term wear was associated with reduced corneal sensitivity. No structural alterations were detected under the conditions of the present study.
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