Evidence map›Paper›PMID 42693199›Full record

ArticleNature neuroscience2026

Priming of CD8

Hao Hu, Peter Bor-Chian Lin, Carisa Zeng, Yongyi Li, Megan E Bosch, Joshua T Emmerson, Prabal Sharma, Ray A Ohara, Wendy Dong, Tong Wu and 21 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Hao HuDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-3622-9897
Peter Bor-Chian LinDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8954-9045
Carisa ZengDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-7108-3873
Yongyi LiDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0009-0009-1001-3095
Megan E BoschDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Joshua T EmmersonDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-6007-4341
Prabal SharmaDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Ray A OharaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7897-3169
Wendy DongDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5663-7372
Tong WuDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-9121-2495
Siling DuDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-1540-3585
Wenqing GaoDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Hong JiangDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Liya YuanDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Xin BaoDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Shasha LiDivision of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Anthony N VomundBursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Petra Erdmann-GilmoreBursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Yichen GuDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Miwei HuDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Jonathan NulmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8887-4532
Timothy M MillerDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.
Wayne M YokoyamaDivision of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0566-7264
Cheryl F LichtiDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-4099-4954
Jeffrey MilbrandtDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5477-7689
Richard J PerrinDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3443-7716
Jonathan KipnisDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3714-517X
Maxim N ArtyomovDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Kenneth M MurphyDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3505-9630
Jason D UlrichDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA. ulrichj@wustl.edu.ORCID http://orcid.org/0000-0002-4743-926X
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA. holtzman@wustl.edu.ORCID http://orcid.org/0000-0002-3400-0856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease and primary tauopathies are marked by changes in adaptive immunity, with increased brain CD8

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.