Reviewnpj drug discovery2026
Closing the recapitulation gap in obesity-conditioned TNBC drug development.
Review in npj drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Preclinical cancer models do not always recapitulate clinical treatment response, as therapeutic response may depend on tissue context the model does not reproduce. Using obesity-conditioned triple-negative breast cancer as a lens, we argue that the tumor microenvironment acts through dual gates-controlling access and altering behavior-and propose the recapitulation gap as a measurable model-to-patient divergence to guide fit-for-purpose drug development.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.