Evidence map›Paper›PMID 42693151›Full record

ArticleScientific reports2026

Metabolic and cardiovascular profiles in diabetes type 2: a comparative analysis of zinc homeostasis and blood pressure-a single center case-control study.

Sara M Eladawy, Heba H Salem, Gehan F Balata, Ahmed A Abdelkader, Mohamed Hany Abdelraouf, Ahmed Mostafa Abdelazem, Mohamed Khaled Ahmed Awad, Shams Abdo Mostafa Hassan, Mohamed Saad Rady Attallah, Merna Magdy Zakaria and 29 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

39 authors.

Sara M EladawyDepartment of Pharmacy Practice, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Heba H SalemCollege of Pharmacy, King Khalid University, 61441, Abha, Kingdom of Saudi Arabia.ORCID 0000-0002-3289-5588
Gehan F BalataDepartment of Pharmacy Practice, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Ahmed A AbdelkaderDepartment of Pharmacy Practice, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Mohamed Hany AbdelraoufStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Ahmed Mostafa AbdelazemStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Mohamed Khaled Ahmed AwadStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Shams Abdo Mostafa HassanStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Mohamed Saad Rady AttallahStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Merna Magdy ZakariaStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Nada Mohamed Sayed RatebStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Aml Abdel Aziz Mohamed ZidanStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Nada Elrekawky Helmy TawfikStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Sara Soliman MousaStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Tasnem Ahmed AliStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Maryam Khaled Attia MohamedStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Mariam Ashraf AbdoStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Asmaa Mohamed HassanStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Eslam Sobhy AbdelazizStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Kholud Ashraf MohamedStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Hedra Asad ThabetStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Rewan Tarek MuhamedStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Dina Hassan El SayedStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Nancy Essam El Hussaini MohamedStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Abdel Rahman Mohamed HashemStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Mariam Khaled MohamedStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
David Magdy Maurice GendiStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Sara Alaa Eldin EssamStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Mark Alkes Rezkalla NouhStudents at Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Hala Esameldin Mohamed KahlaDepartment of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Shereen Sadik El SwayDepartment of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Rasha Sobh Mohamed FaragDepartment of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Bassant Saeed GaberDepartment of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Amal Ahmed MohamedDepartment of Biochemistry and Molecular Biology, National Hepatology and Tropical Research Institute, Cairo, Egypt.
Mohamed Said MahmoudDepartment of Biochemistry and Molecular Biology, National Hepatology and Tropical Research Institute, Cairo, Egypt.
Naglaa FawzyNational Institute for Diabetes and Endocrinology, Cairo, Egypt.
Amira Mohamed FadlNational Institute for Diabetes and Endocrinology, Cairo, Egypt.
Ali Mahmoud AbdelkaderDepartment of General Surgery, Faculty of Medicine, Badr University, Cairo, Egypt.
Hany N AzzamDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt. h_any89@hotmail.com.ORCID 0000-0001-7236-0126

Funding

Deanship of Research and Graduate Studies at King Khalid University RGP1/208/46
6 · The paper itself

Abstract

Zinc plays an important role in glucose metabolism and lipid regulation, and its imbalance has been implicated in the development of type 2 diabetes, metabolic syndrome, and dyslipidemia. A case-control study was conducted on 100 patients with type 2 diabetes and 95 controls. Serum zinc levels, metabolic panel and Blood pressure, were measured. Demographic and treatment-related factors were assessed to evaluate their potential influence on trace element status. Moreover, dietary zinc consumption was estimated. Diabetic patients had significantly lower serum zinc levels compared to non-diabetic participants despite comparable intake. In addition, each unit (mcg/dL) increase in serum zinc was associated with 10% lower odds of diabetes prevalence (p = 0.003). Total TC, TG, and LDL were all significantly increased in patients with diabetes (p < 0.001), each 1 mg/dL increase in LDL-cholesterol increased the odds of zinc deficiency by 4% (p = 0.03). Individuals with diabetes had significantly lower diastolic blood pressure as compared to healthy participants (p = 0.01). People with diabetes display different blood pressure and lipid patterns, as well as lower serum zinc concentrations, despite having dietary zinc intake comparable to those without diabetes. Higher serum zinc levels are associated with reduced odds of having diabetes. However, because these findings are based on cross-sectional data, further longitudinal and intervention studies are needed to determine the most effective zinc formulations and dosing regimens.

Indexed as

Blood PressureDiabetes Mellitus, Type 2ZincAgedCase-Control StudiesFemaleHomeostasisHumansLipidsMaleMiddle AgedLipidsZincDiastolic blood pressureSerum zincType 2 diabetesZinc intake

Identifiers

PMID42693151
PMCPMC13542261

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