Evidence map›Paper›PMID 42693143›Full record

ArticleNature communications2026

CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis.

Minghe Fan, Ziyang Zhang, Wei Xu, Yuwei Liu, Ruoxuan Wang, Wenqin Hao, Sihan Huo, Yuyao Guo, Lina Wang, Ang Lv and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Minghe Fan *State Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Ziyang Zhang *State Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Wei Xu *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery/Sarcoma Center, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Yuwei LiuDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, 100191, China.
Ruoxuan WangState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Wenqin HaoState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Sihan HuoState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Yuyao GuoState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Lina WangState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China.
Ang LvKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery/Sarcoma Center, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Xiangyu LiuInternational Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen, 518055, China. liuxiangyu@szu.edu.cn.
Wei WangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, 100191, China. wangwei83427@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-4923-5412
Chuanhui HanState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China. chuanhui.han@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-7634-8471
Ying ZhaoState Key Laboratory of Molecular Oncology, Frontiers Science Center for Cancer Integrative Omics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Cancer Hospital and Institute, Peking University Health Science Center, Beijing, 100191, China. zhaoying0812@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-3995-0639

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32470966National Natural Science Foundation of China (National Science Foundation of China) 82425039 and 82173020
6 · The paper itself

Abstract

Cancer-associated fibroblasts comprise diverse functionally distinct cellular subsets, with certain subpopulations exerting pivotal influence in shaping the pancreatic cancer immune microenvironment. Here we show that Lin28b

Indexed as

Cancer-Associated FibroblastsCarcinoma, Pancreatic DuctalMembrane ProteinsPancreatic NeoplasmsRNA-Binding ProteinsTumor MicroenvironmentAnimalsCell Line, TumorcGAS-STING Signaling PathwayDendritic CellsGene Expression Regulation, NeoplasticHumansMiceSignal TransductionSTING ProteinLIN28B protein, humanMembrane ProteinsRNA-Binding ProteinsSTING1 protein, humanSTING Protein

Identifiers

PMID42693143
PMCPMC13542369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.