Evidence map›Paper›PMID 42693119›Full record

ArticleNature communications2026

DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly.

Agnese Pisano, Jessie Bourdeaux, Jarosław Mazur, Florine Roses, Yves Romeo, Elisabeth Petfalski, Tobias von Arx, Daniela Portugal-Calisto, Michaela Oborská-Oplová, Cohue Peña and 4 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Agnese PisanoInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Jessie BourdeauxCBI, Université de Toulouse, CNRS, CBI, Toulouse, France.
Jarosław MazurInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1677-011X
Florine RosesCBI, Université de Toulouse, CNRS, CBI, Toulouse, France.
Yves RomeoCBI, Université de Toulouse, CNRS, CBI, Toulouse, France.
Elisabeth PetfalskiCentre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Tobias von ArxInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Daniela Portugal-CalistoInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Michaela Oborská-OplováInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Cohue PeñaInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Clément ChapatCBI, Université de Toulouse, CNRS, CBI, Toulouse, France.
David TollerveyCentre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2894-2772
Anthony K HenrasCBI, Université de Toulouse, CNRS, CBI, Toulouse, France. anthony.henras@utoulouse.fr.
Vikram Govind PanseInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland. vpanse@imm.uzh.ch.ORCID http://orcid.org/0000-0002-4770-7068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA exosome-associated helicase Mtr4/MTR4 (yeast/human) is recruited by adaptor proteins bearing Arch-Interacting Motifs (AIMs) to selectively degrade RNA substrates. Although the exosome targets diverse RNAs, only a few adaptors have been identified. Here, we extend the inventory of human adaptors to include a pre-tRNA splicing-ligase complex component, a spliceosome-associated factor, and DNTTIP2, a constituent of the small ribosomal subunit (40S) precursor, the 90S pre-ribosome. Structure-guided studies reveal how the DNTTIP2

Indexed as

Exosome Multienzyme Ribonuclease ComplexExosomesRibosomesExoribonucleasesHumansRNA-Binding ProteinsRNA HelicasesRNA PrecursorsExoribonucleasesEXOSC10 protein, humanExosome Multienzyme Ribonuclease ComplexRNA-Binding ProteinsRNA HelicasesRNA Precursors

Identifiers

PMID42693119
PMCPMC13542088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.