Evidence map›Paper›PMID 42693106›Full record

ArticleNature communications2026

Longer-lived mammals exhibit greater evolutionary conservatism and epigenetic modification at cancer-associated loci.

Xiaoxiao Zhang, Meng Li, Xin Tong, Weixiao Chen, Gaoming Liu, Pingfen Zhu, Juan Du, Yue Sun, Xiao Wang, Xuming Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoxiao Zhang *State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-5920-4628
Meng Li *State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-2453-1821
Xin TongDepartment of Dermatology, First Medical Centre of Chinese PLA General Hospital, Beijing, China.ORCID http://orcid.org/0000-0002-7953-3891
Weixiao ChenState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Gaoming LiuState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Pingfen ZhuState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-2336-8898
Juan DuSchool of Life Science, Shanxi University, Taiyuan, China.
Yue SunSchool of Biological Sciences, Guizhou Education University, Guiyang, China.
Xiao WangState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xuming ZhouState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. zhouxuming@ioz.ac.cn.ORCID http://orcid.org/0000-0002-1100-6294

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32270437
6 · The paper itself

Abstract

Peto's paradox underscores the puzzling disconnect between organismal lifespan, body size, and cancer incidence. Here, we investigate this relationship by examining the evolutionary rates of human cancer-associated sites across 58 mammalian species. While overall evolutionary rates at cancer-associated loci do not differ significantly between long-lived and short-lived species, cancer-associated sites show greater evolutionary conservation relative to non-cancer sites within long-lived mammals but not within short-lived mammals. Furthermore, long-lived species exhibit a pronounced enrichment of m

Indexed as

Epigenesis, GeneticEvolution, MolecularLongevityMammalsNeoplasmsAnimalsGene Expression Regulation, NeoplasticHumansMaleRNA, MessengerRNA MethylationRNA, Messenger

Identifiers

PMID42693106
PMCPMC13542213

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.