Evidence map›Paper›PMID 42692902›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2026

Does ductal subtype predict outcomes after resection of IPMN-derived pancreatic cancer? An international multi-center retrospective study.

Kate Mlouk, Camila Hidalgo Salinas, Jonah Levine, Joseph R Habib, Madeleine Hunter, Rami Imam, D Brock Hewitt, Michael D Kluger, Katherine Morgan, Lois A Daamen and 5 more

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Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Kate MloukNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Camila Hidalgo SalinasNYU Grossman School of Medicine, Department of Surgery, New York, USA; Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, United Kingdom; Department for Continuing Education, University of Oxford, Oxford, United Kingdom.
Jonah LevineNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Joseph R HabibNYU Grossman School of Medicine, Department of Surgery, New York, USA; Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, Department of Surgery, Utrecht, the Netherlands.
Madeleine HunterNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Rami ImamNYU Grossman School of Medicine, Department of Surgery, New York, USA.
D Brock HewittNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Michael D KlugerNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Katherine MorganNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Lois A DaamenRegional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center & St. Antonius Hospital Nieuwegein, Department of Surgery, Utrecht, the Netherlands; University Medical Center Utrecht, Division of Imaging and Oncology, Utrecht, the Netherlands.
Christopher L WolfgangNYU Grossman School of Medicine, Department of Surgery, New York, USA.
I Quintus MolenaarUniversity Medical Center Utrecht, Division of Imaging and Oncology, Utrecht, the Netherlands.
Marc G BesselinkDepartment of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, the Netherlands.
Ammar A JavedNYU Grossman School of Medicine, Department of Surgery, New York, USA.
Greg D SacksNYU Grossman School of Medicine, Department of Surgery, New York, USA. Electronic address: Greg.sacks@nyulangone.org.

Funding

Optimizing surgical decision-making for premalignant pancreatic cystsK08CA293277 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Greg Sacks · 2025 to 2026
$516k
NCI NIH HHS K08 CA293277
6 · The paper itself

Abstract

backgroundAlthough main duct (MD) and branch duct (BD) IPMNs differ in preoperative risk of malignant transformation, it remains unclear whether ductal subtype influences outcomes once invasive carcinoma develops and is resected. We compared recurrence and survival outcomes between these subtypes.

methodsWe identified patients with resected IPMN-derived pancreatic ductal adenocarcinoma (PDAC) from three institutions. Overall survival (OS) and recurrence-free survival (RFS) were estimated using Kaplan-Meier methods and compared with log-rank tests. Multivariable Cox regression models adjusted for age, T-stage, N-stage, histologic subtype, and adjuvant chemotherapy.

resultsAmong 136 patients, 106 (78%) had MD-derived and 30 (22%) had BD-derived IPMN-associated PDAC. Median OS was 36.6 months and did not differ by subtype on log-rank (p = 0.472) or multivariable analysis (HR 0.45, 95% CI 0.15-1.31; p = 0.143). Median RFS was 41.8 months without significant difference by subtype on log-rank (p = 0.362) or adjusted analysis (HR 0.56, 95% CI 0.21-1.46; p = 0.234).

conclusionsIn patients with resected IPMN-derived PDAC, ductal subtype was not significantly associated with OS. While clinically meaningful differences in RFS cannot be excluded, these findings suggest that once invasive cancer arises and is resected, ductal subtype alone may not provide additional prognostic information.

Identifiers

PMID42692902
PMCPMC13589809

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