Evidence map›Paper›PMID 42692794›Full record

ArticleLife science alliance2026

Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97

Daniella Munro, Maike Reinders, Aikaterini Pravi, Johannes van den Boom, Pinki Gahlot, Ekaterina Isaakova, Caio Ab Oliveira, Dominik Boos, Petra Beli, Hemmo Meyer

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PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniella MunroMolecular Biology I, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0009-0007-4196-5713
Maike ReindersMolecular Biology I, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-4425-3494
Aikaterini PraviMolecular Genetics II, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.
Johannes van den BoomMolecular Biology I, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-2075-9351
Pinki GahlotMolecular Biology I, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0009-0000-8175-045X
Ekaterina IsaakovaInstitute of Molecular Biology (IMB), Mainz, Germany.
Caio Ab OliveiraInstitute of Molecular Biology (IMB), Mainz, Germany.
Dominik BoosMolecular Genetics II, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0003-0018-4375
Petra BeliInstitute of Molecular Biology (IMB), Mainz, Germany.
Hemmo MeyerMolecular Biology I, Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany hemmo.meyer@uni-due.de.ORCID https://orcid.org/0000-0003-1883-1796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The AAA ATPase VCP/p97 has emerged as a critical regulator of ubiquitin and chromatin-associated processes but progress in understanding has been hampered by the complexity of p97 functions and the various p97 cofactors involved. Here, we combined ubiquitin profiling with acutely induced degradation of the Ufd1 subunit of the p97 ubiquitin adapter, Ufd1-Npl4, in human cells. We identified a set of chromatin regulators, HUS1, XRCC1, MORF4L1, and the cohesin subunit RAD21 as targets of p97

Indexed as

Cell Cycle ProteinsChromosomal Proteins, Non-HistoneNuclear ProteinsValosin Containing ProteinAdenosine TriphosphatasesChromatinCohesinsDNA-Binding ProteinsDNA DamageDNA ReplicationHumansIntracellular Signaling Peptides and ProteinsPhosphoproteinsProteolysisS PhaseUbiquitinationAdenosine TriphosphatasesCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsNPLOC4 protein, humanNuclear Proteinsp97 ATPasePhosphoproteinsRAD21 protein, humanUFD1 protein, humanValosin Containing ProteinVCP protein, human

Identifiers

PMID42692794
PMCPMC13542637

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.