ArticleThe Journal of allergy and clinical immunology2026
IL-9R/Arg1 pathway promotes polyamine metabolism in human airway macrophages.
Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLung macrophages are central regulators of inflammatory responses in the airways and lung parenchyma. Macrophages function as conduits for cytokine function in the inflammatory milieu. We previously demonstrated that IL-9-responsive macrophages are essential for allergic lung inflammation in an arginase 1 (Arg1) pathway.
objectiveWe defined the IL-9/Arg1/polyamine pathway in human macrophages from model systems and asthmatic patient samples.
methodsUsing humanized NSG-Quad mice treated with intranasal IL-9 and patient bronchoalveolar lavage (BAL) samples, we evaluated macrophage phenotypes via flow cytometry, bulk RNA sequencing, and metabolic assays.
resultsTwo distinct human lung macrophage populations were defined by the expression of CD43. IL-9 promoted the expansion of IL-9R
conclusionsIL-9-responsive CD206
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