Evidence map›Paper›PMID 42692008›Full record

ArticleStem cell reports2026

Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface.

Johanna Grinat, María Moya-Navamuel, Paula Blanco-Cueto, Claudia Alemán-Juanes, Nathaly Hernández-Díaz, Maravillas Mellado-López, Amparo Galán, Luke A Noon, Deborah J Burks, Katrien De Clercq and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Johanna GrinatCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain. Electronic address: jgrinat@cbm.csic.es.
María Moya-NavamuelCentro de Investigación Príncipe Felipe, Valencia, Spain.
Paula Blanco-CuetoCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Claudia Alemán-JuanesCentro de Investigación Príncipe Felipe, Valencia, Spain.
Nathaly Hernández-DíazCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Maravillas Mellado-LópezCentro de Investigación Príncipe Felipe, Valencia, Spain.
Amparo GalánCentro de Investigación Príncipe Felipe, Valencia, Spain.
Luke A NoonCentro de Investigación Príncipe Felipe, Valencia, Spain.
Deborah J BurksCentro de Investigación Príncipe Felipe, Valencia, Spain.
Katrien De ClercqDepartment of Development and Regeneration, KU Leuven, Leuven, Belgium.
Jorge López-TelloInstitute for Biomedical Research Sols-Morreale, Madrid, Spain; Department of Physiology, Faculty of Medicine. Autonomous University of Madrid, Madrid, Spain.
Vicente Pérez-GarcíaCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain; Centro de Investigación Príncipe Felipe, Valencia, Spain. Electronic address: vperez@cbm.csic.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The placental labyrinth is the primary site of maternal-fetal exchange, and its disruption contributes to placental insufficiency and fetal growth restriction (FGR). Here, we identify insulin receptor substrate 2 (IRS2) as a key regulator of mouse placental labyrinth development. Irs2 is expressed in the syncytiotrophoblast (SynT) layers of the labyrinth, where it integrates growth factor signaling during placental morphogenesis. Loss of IRS2 disrupts labyrinth organization, causing defective SynT-II differentiation, impaired trophoblast fusion, and reduced fetal vascularization. Using CRISPR-Cas9-engineered Irs2

Indexed as

Cell DifferentiationInsulin Receptor Substrate ProteinsPlacentaTrophoblastsAnimalsDNA-Binding ProteinsFemaleHumansInsulin-Like PeptidesMicePhosphatidylinositol 3-KinasesPregnancyProto-Oncogene Proteins c-aktSignal TransductionStem CellsTranscription FactorsDNA-Binding ProteinsGcm1 protein, mouseInsulin-Like PeptidesInsulin Receptor Substrate ProteinsIrs2 protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTranscription FactorsCRISPR-Cas9 technologyfetal growth restrictionfetal vasculatureIGFinsulin-like growth factor signalingmaternal-fetal interfaceplacental labyrinthsyncytiotrophoblasttrophoblast stem cells

Identifiers

PMID42692008
PMCPMC13681323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.