Evidence map›Paper›PMID 42691758›Full record

ArticleThe journal of physiological sciences : JPS2026

Relationship between sensory irritation on skin surface and TRP channel activation.

Fumitaka Fujita, Masayuki Takaishi, Shizuka Iwashita, Kiyomi Yoshikawa, Maki Sawada, Hironori Shimizu, Moriaki Nagamatsu, Yuko Shiomi, Takeshi Hara, Kenya Ishida and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fumitaka FujitaMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan; Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: fujita-f@phs.osaka-u.ac.jp.
Masayuki TakaishiMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan; Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamadaoka, Suita, Osaka 565-0871, Japan.
Shizuka IwashitaMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan.
Kiyomi YoshikawaMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan.
Maki SawadaMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan.
Hironori ShimizuMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan.
Moriaki NagamatsuMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan.
Yuko ShiomiMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan.
Takeshi HaraMandom Corp., 5-12, Juniken-Cho, Chuoku, Osaka 540-8530, Japan; Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamadaoka, Suita, Osaka 565-0871, Japan.
Kenya IshidaTakasago International Corporation, 1-5-1, Nishiyawata, Hiratsuka, Kanagawa 254-0073, Japan.
Kunitoshi UchidaLaboratory of Functional Physiology, School of Food and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka 422-8526, Japan.
Yoshiro SuzukiDepartment of Physiology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Iwate, Shiwa-gun 028-3694, Japan.
Makoto TominagaThermal Biology Research Group, Nagoya Advanced Research and Development Center, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. Electronic address: tominaga@nips.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanisms underlying sensory irritation caused by chemical stimuli on the skin surface remain unknown. Recently, it has been clarified that TRPA1 and TRPV1 are important for sensing nociceptive and temperature stimuli. This study aimed to clarify the mechanism of hTRPA1 and hTRPV1 in sensory irritation on the skin by evaluating the effects of anti-bacterial agents, ethanol, or polyols using electro-physiological methods in HEK293 cells. Parabens (1 mM) activated hTRPA1 in an alkyl chain length-dependent manner. Conversely, high concentrations (>500 mM) of ethanol and polyols activate hTRPV1. The intensities of sensory irritation caused by anti-bacterial agents or polyols correlated with their abilities to activate TRPA1 or TRPV1, respectively. Analogs of known TRPA1 antagonists were screened for their TRPA1 inhibitory activity. Arbanol was identified as a novel TRPA1 inhibitor that can be used to reduce sensory irritation on the skin surface. TRP channels are crucial for sensory irritation on the skin surface.

Indexed as

ArbanolParabenPolyolSensory irritationTRPA1TRPV1

Identifiers

PMID42691758
PMCPMC13571459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.