Evidence map›Paper›PMID 42691696›Full record

ArticleMolecular pharmacology2026

Piezo1 agonists are potent off-target inhibitors of the Kv1.3 channel via gating modification.

Kyan Huang, Heesung Shim, Heike Wulff, Hai M Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyan HuangDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, California.
Heesung ShimPhysical and Life Sciences, Lawrence Livermore National Laboratory, Livermore, California.
Heike WulffDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, California.
Hai M NguyenDepartment of Pharmacology, School of Medicine, University of California, Davis, Davis, California. Electronic address: hmnguye@health.ucdavis.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanosensitive Piezo1 channel is crucial for the regulation of calcium (Ca

Indexed as

Ion Channel GatingIon ChannelsKv1.3 Potassium ChannelThiadiazolesAnimalsCalciumHumansMacrophagesMembrane PotentialsMiceMice, Inbred C57BLMolecular Docking SimulationMolecular Dynamics SimulationPyrazinesCalciumIon ChannelsKv1.3 Potassium ChannelPiezo1 protein, mousePyrazinesThiadiazolesyoda-1Ca(2+) signalingInflammationIon channel pharmacologyKv1.3Molecular dockingPiezo1

Identifiers

PMID42691696
PMCPMC13688990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.