ArticleScience (New York, N.Y.)2026
Early-life colonization with
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
33 authors.
Alexa Semon *Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-0551-1446
Haider S Manzer *Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-2864-6212
Orlaith KeenanDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-6973-1424
Tiffany H ZhouDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0004-8695-9243
Connor TiffanyDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-8188-7720
Qianxuan SheDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Montana KnightDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-5229-4122
Ashley S WeissDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0008-7162-4829
Kassy DonohoeDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0001-9400-543X
Brendan T MorrowDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-5158-5510
Rochelle C GloverDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-5699-0184
Maria E KovalikInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2913-1533
Ceylan TanesThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kyle BittingerThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3472-5934
Babette S ZemelDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-6164-7348
Gary D WuDivision of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1829-8795
Michael A SilvermanThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-7876-4399
Jeffrey S GerberGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-3076-3186
Rubén Cano RodríguezDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
D Borden LacyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-2273-8121
Tatiana A KarakashevaDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-9070-2804
Mohamad-Gabriel AlamehDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Drew WeissmanDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1501-6510
Stacey L Schultz-CherryDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2021-727X
Jason W RoschDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Paul J PlanetThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-0543-0539
Ahmed M MoustafaThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-9949-6936
Emma E FurthDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9309-985X
Michael C AbtInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7351-2061
Judith R KelsenDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-0038-318X
Maire A ConradThe Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3561-3029
Kathryn E HamiltonDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-9575-2499
Joseph P ZackularDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-3228-3055
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5MInfant Growth and Microbiome Study 2R01DK107565 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WU, GARY D., ZEMEL, BABETTE S · 2015 to 2019
$3.6MStructural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2MLeveraging early-life microbes to prevent type 1 diabetesR01DK133453 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Michael A Silverman · 2023 to 2026
$3.1MMolecular interactions in the gut microbiota during early life colonization and perturbationR35GM138369 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph Paul Zackular · 2020 to 2026
$2.7MInvestigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantationR01AI158830 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABT, MICHAEL C. · 2021 to 2025
$2.4MTraining in Microbial Pathogenesis and GenomicsT32AI141393 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D, ZHU, JUN · 2019 to 2023
$1.3MAperio VERSA Digital Slide Scanner, eSlide Manager Database, and Advanced Image Analysis SoftwareS10OD023465 · OD · UNIVERSITY OF PENNSYLVANIA · PI DURHAM, AMY CLEVELAND · 2018 to 2018
$329kNCATS NIH HHS UL1 TR001878NCI NIH HHS P30 CA016520NIAID NIH HHS R01 AI158830NIAID NIH HHS R37 AI095755NIAID NIH HHS T32 AI141393NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK107565NIDDK NIH HHS R01 DK133453NIGMS NIH HHS R35 GM138369NIH HHS S10 OD023465
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clostridioides difficileClostridium InfectionsImmunity, Maternally-AcquiredIntestinal MucosaAnimalsBacterial ToxinsBacterial VaccinesCell DifferentiationFemaleHumansInfantMicemRNA VaccinesStem CellsVaccinationBacterial ToxinsBacterial VaccinesmRNA Vaccines
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.