Evidence map›Paper›PMID 42690608›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations.

Jasmin Hasanovic, Paul Friedrich Esslinger, Veronika Lummer, Heiner Nebelung, Leo Misera, Ralf-Thorsten Hoffmann, Johanna Kirchberg, Marius Distler, Jürgen Weitz, Daniel E Stange and 1 more

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Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jasmin HasanovicDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Paul Friedrich EsslingerDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Veronika LummerDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Heiner NebelungFaculty of Medicine, Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Leo MiseraFaculty of Medicine, Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Ralf-Thorsten HoffmannFaculty of Medicine, Institute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Johanna KirchbergDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Marius DistlerDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Jürgen WeitzDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Daniel E StangeDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Felix MerbothDepartment of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. felix.merboth@ukdd.de.ORCID http://orcid.org/0000-0003-2540-6421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia is an important prognostic factor in gastrointestinal malignancies, but CT-based definitions vary. This study evaluated recently published computed tomography (CT)-based cut-offs for skeletal muscle index (SMI) and psoas muscle thickness normalized to height (PMTH), derived from a young, presumably healthy reference population according to recommendations of the European Working Group on Sarcopenia in Older People (EWGSOP), in patients undergoing surgery for gastric cancer.

methodsThis retrospective, single-center cohort study included patients who underwent surgery for gastric cancer between 2013 and 2018. Preoperative CT was used to assess SMI and PMTH. The recently published reference cut-offs were compared with the established definitions of Prado et al. (SMI) and Gu et al. (PMTH). Overall survival (OS) and recurrence-free survival (RFS) were the primary and secondary endpoints, respectively.

resultsData from 212 patients with complete 5-year follow-up were analyzed. The reference cut-offs significantly discriminated OS and RFS (SMI, both p < 0.001; PMTH, both p = 0.002), whereas the established cut-offs showed weaker or no discrimination. Patients with both low SMI and low PMTH had the worst OS and RFS (both p < 0.001). Combined low SMI and low PMTH was associated with worse OS in univariable analysis (HR 2.57, 95% CI 1.54-4.30, p < 0.001) and remained independently associated in multivariable analysis (HR 1.83, 95% CI 1.01-3.30; p = 0.046).

conclusionsThe recently published CT-based reference cut-offs for SMI and PMTH provided consistent prognostic stratification after gastric cancer resection, and their combined use identified patients with particularly poor long-term survival.

Indexed as

Computed tomographyGastric cancerPrognosisPsoas muscle thicknessSarcopeniaSkeletal muscle index

Identifiers

PMID42690608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.