Evidence map›Paper›PMID 42690582›Full record

ArticleGeneral thoracic and cardiovascular surgery2026

Impact of preoperative nutritional status on longitudinal changes in pulmonary function and prognosis after lung cancer surgery.

Kentaro Miura, Daisuke Nakamura, Sachie Koike, Shuji Mishima, Yukihiro Terada, Shunichiro Matsuoka, Hirotaka Kumeda, Takashi Eguchi, Kazutoshi Hamanaka, Kimihiro Shimizu

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Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kentaro MiuraDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Daisuke NakamuraDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Sachie KoikeDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Shuji MishimaDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Yukihiro TeradaDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Shunichiro MatsuokaDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Hirotaka KumedaDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Takashi EguchiDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Kazutoshi HamanakaDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
Kimihiro ShimizuDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. kmshimizu@gmail.com.ORCID http://orcid.org/0000-0003-4076-5174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePreoperative nutritional status is a known prognostic factor in lung cancer surgery. However, its effect on postoperative pulmonary function over time remains unclear. This study evaluated the association between preoperative nutritional status and longitudinal respiratory changes andoutcomes after curative resection.

methodsPatients who underwent resection for non-small cell lung cancer between January 2020 and December 2024 were prospectively analyzed. Patients were classified by prognostic nutritional index (PNI) into normal (PNI ≥ 50) and malnutrition (PNI < 50) groups. Pulmonary function, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), and diffusing capacity of the lung for carbon monoxide (%DLco), was assessed preoperatively and at 6 and 12 months postoperatively. Changes were compared between lobectomy and sublobar resection by nutritional status. Overall survival (OS) and recurrence-free survival (RFS) were analyzed.

resultsOf 551 surgical patients, 294 were included. Low PNI was associated with significantly worse OS and RFS (P < 0.001 and P = 0.005, respectively). Patients with low PNI undergoing lobectomy showed poorer survival outcomes in unadjusted analyses, although interaction analysis demonstrated no significant modification of the prognostic impact of PNI by surgical procedure. Among patients undergoing lobectomy, postoperative FVC recovery differed according to nutritional status (p=0.016), whereas no significant differences were observed in FEV1.0 or %DLco.

conclusionsLow preoperative PNI was associated with poorer survival and may be associated with postoperative pulmonary functional recovery after lung resection. Preoperative nutritional status may warrant consideration alongside established clinical and oncological factors when planning surgical treatment.

Indexed as

Forced vital capacityLung cancerOverall survivalPrognostic nutritional indexRespiratory function

Identifiers

PMID42690582

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