Evidence map›Paper›PMID 42690422›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Role of DLL4 in Neutrophil Aging and Impaired Clearance in Sepsis.

Hui Jin, Saoirse Holland, Alok Jha, Monowar Aziz, Ping Wang

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui JinCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA.
Saoirse HollandCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA.
Alok JhaCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA.
Monowar Aziz *Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA. maziz1@northwell.edu.ORCID http://orcid.org/0000-0002-8195-4505
Ping Wang *Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY, 11030, USA. pwang@northwell.edu.ORCID https://orcid.org/0000-0002-1557-0394

Funding

NIH HHS R35GM118337 and R01HL076179
6 · The paper itself

Abstract

Sepsis remains a major cause of mortality, largely due to acute lung injury (ALI) driven by excessive neutrophil mediated inflammation. We recently identified a pathogenic subset of DLL4⁺ neutrophils that expands in inflamed lungs and promotes ALI, yet the underlying mechanisms remain unclear. Here, we investigated how DLL4⁺ neutrophils modulate alveolar macrophage (AM) function to exacerbate lung injury. AMs were treated with DLL4⁺ neutrophils or recombinant DLL4 (rmDLL4), and macrophage polarization was assessed by flow cytometry. Conditioned medium was subsequently applied to bone marrow-derived neutrophils (BMDNs) to evaluate neutrophil aging and CD47 expression (don't eat me signal on neutrophils). We showed that DLL4⁺ neutrophils activate the Notch1 signaling pathway in AMs, promoting toward a proinflammatory M1 phenotype. M1 cells markedly upregulate leukotriene B4 (LTB4) production through 5-lipoxygenase activation (5-LOX), inducing the accumulation of aged neutrophils (CXCR4

Indexed as

Intracellular Signaling Peptides and ProteinsMacrophages, AlveolarNeutrophilsSepsisAcute Lung InjuryAdaptor Proteins, Signal TransducingAnimalsCalcium-Binding ProteinsCD47 AntigenLeukotriene B4LungMaleMiceMice, Inbred C57BLPhagocytosisReceptor, Notch1Adaptor Proteins, Signal TransducingCalcium-Binding ProteinsCD47 AntigenDLL4 protein, mouseIntracellular Signaling Peptides and ProteinsLeukotriene B4Notch1 protein, mouseReceptor, Notch1Acute lung injuryAlveolar macrophagesDLL4⁺ neutrophilsDLL4-Notch1 signalingLeukotriene B4Neutrophil agingSepsis

Identifiers

PMID42690422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.