ArticleRevista da Associacao Medica Brasileira (1992)2026
Low pregnancy-associated plasma protein-A and serum urotensin-II in 11-14 weeks gestation: case-control study.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis case-control study aims to investigate the relationship between low pregnancy-associated plasma protein-A levels and serum urotensin-II concentrations between the 11th and 14th weeks of pregnancy.
methodsThis study was conducted between October 2024 and October 2025 at the perinatology outpatient clinic of a Training and Research Hospital in Istanbul. A total of 84 women were consecutively included and divided into case and control groups based on pregnancy-associated plasma protein-A results. Written consent and a descriptive form were obtained. Combined screening tests were performed, and blood samples were collected for urotensin-II measurement.
resultsNo significant difference was observed between the case and control groups in terms of urotensin-II concentration. A statistically significant positive correlation was found between pregnancy-associated plasma protein-A levels and urotensin-II concentrations. Each 1 mIU/mL increase in pregnancy-associated plasma protein-A concentration was associated with an approximate 36.45 ng/mL increase in urotensin-II concentration.
conclusionIn this study, no significant association was demonstrated between pregnancy-associated plasma protein-A levels and urotensin-II levels in case and control groups; however, a correlation was identified between pregnancy-associated plasma protein-A levels and urotensin-II concentrations.
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