Trial reportSao Paulo medical journal = Revista paulista de medicina2026
The effect of BIS-guided sevoflurane anesthesia on postoperative nausea and vomiting in pediatric adenoidectomy: a prospective randomized controlled trial.
Trial report in Sao Paulo medical journal = Revista paulista de medicina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07189845 (Effect of Bispectral Index), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Effect of Bispectral Index (BIS)-Guided Anesthesia on Postoperative Nausea and Vomiting in Children Aged 3 to 8 Years: A Prospective Randomized Controlled Trial
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6 authors.
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Abstract
backgroundPostoperative nausea and vomiting (PONV) is a frequent complication in pediatric patients undergoing adenoidectomy. Bispectral index (BIS) monitoring, an electroencephalography-based method for assessing anesthetic depth, enables individualized sevoflurane titration and may reduce unnecessary exposure to volatile anesthetics.
objectivesTo determine whether BIS-guided sevoflurane anesthesia reduces PONV in children undergoing adenoidectomy. DESIGN AND
settingSingle-center, prospective, randomized, assessor-blinded trial conducted at University of Health Sciences, Kocaeli City Hospital, Kocaeli, Türkiye.
methodsFifty-eight children aged 3-8 years (American Society of Anesthesiologists score I-II) undergoing elective adenoidectomy were randomized to BIS-guided anesthesia (n = 29) or standard care (n = 29). Both groups received sevoflurane anesthesia. The primary outcome was PONV within the first 24 postoperative hours. Secondary outcomes were emergence time, total sevoflurane consumption, remifentanil dose, and rescue antiemetic use.
resultsPONV within 24 hours occurred less frequently in the BIS-guided group than in controls (p = 0.015), with the greatest between-group differences observed at 0-1 hour and 1-6 hours. Sevoflurane consumption and emergence time were lower in the BIS-guided group (p < 0.05). BIS-guided anesthesia was independently associated with lower odds of PONV (OR = 0.212; 95% CI: 0.067-0.675; p = 0.009).
conclusionsBIS monitoring may be a useful strategy for optimizing anesthetic depth and reducing early PONV in pediatric patients. CLINICAL
trial registrationClinicalTrials.gov (NCT07189845). Available at: https://clinicaltrials.gov/study/NCT07189845.
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