Evidence map›Paper›PMID 42690289›Full record

ReviewJournal of assisted reproduction and genetics2026

Effects of assisted reproductive techniques on offspring cardiovascular health: a systematic review and meta-analysis.

Andrea Crafa, Rossella Cannarella, Rosita A Condorelli, Sandro La Vignera, Nicolás Garrido Puchalt, Aldo E Calogero

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea CrafaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-8311-9095
Rossella CannarellaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy. rossella.cannarella@unict.it.
Rosita A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Nicolás Garrido PuchaltIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), and Faculty of Health Sciences, Universidad Europea de Valencia, Valencia, Spain.
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assisted reproductive techniques (ART) are increasingly used worldwide. Concerns persist regarding the long-term cardiovascular health of ART-conceived offspring. To systematically review and meta-analyze cardiovascular, vascular, and echocardiographic outcomes in ART-conceived offspring compared with naturally conceived children. PubMed and Scopus were searched from database inception to January 2025. Reference lists of eligible articles were manually screened. Searches included terms related to assisted reproductive technologies, offspring, and cardiovascular outcomes. Only human studies published in English were included. Observational cohort, cross-sectional, and case-control studies evaluating cardiovascular outcomes in ART-conceived offspring with a naturally conceived comparison group were eligible. Studies without relevant outcomes, lacking a control group, or including populations with genetic conditions affecting cardiovascular health were excluded. Two reviewers independently screened studies, with disagreements resolved by a third investigator. Eighty-one studies met inclusion criteria. Data extraction was independently performed by two reviewers following PRISMA and MOOSE guidelines. Risk of bias and study quality were assessed using the Cambridge Quality Checklist. Meta-analyses were conducted using fixed- or random-effects models according to heterogeneity (I

Indexed as

Assisted reproductive techniqueCardiovascular outcomesMeta-analysisMeta-regressionOffspring healthSystematic review

Identifiers

PMID42690289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.