Evidence map›Paper›PMID 42690277›Full record

ArticleNeurochemical research2026

Mild Hypothermia Alleviates Ischemia and Reperfusion Injury by Activating PINK1/Parkin Mitophagy.

Kailan Deng, Di Zhang, Yidan Chen, Qiumin Shao, Qian Zhang, Dan Wang, Fangyan Gong, Qin Li, Yue Wan, Mingmin Yan

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Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kailan DengDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China.
Di ZhangWuhan University of Science and Technology, Wuhan, 430081, China.
Yidan ChenDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Qiumin ShaoDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China.
Qian ZhangDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China.
Dan WangDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China.
Fangyan GongDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China.
Qin LiDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China.
Yue WanDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China. wylydia@aliyun.com.
Mingmin YanDepartment of Neurology, Hubei NO. 3 People's Hospital, School of Medicine, Jianghan University, Wuhan, 430033, China. 2009203020074@whu.edu.cn.ORCID https://orcid.org/0000-0002-0331-6372

Funding

Health Commission of Hubei Province Scientific Research Project No. WJ2025Q044National Natural Science Foundation of China No. 82301439Opening Project of Hubei Key Laboratory of Cognitive and Affective Disorders No.HBCAD2025-16
6 · The paper itself

Abstract

Ischemia-reperfusion (IR) injury is characterized by significant neuronal apoptosis and mitochondrial damage.Despite significant advancements in understanding the pathophysiological mechanisms of IR, effective therapeutic strategies remain limited. Previous studies have shown that mild hypothermia (MH) can significantly alleviate brain IR injury by reducing neuronal apoptosis and mitochondrial damage, while mitophagy plays a crucial role in maintaining cellular self-protection and mitochondrial homeostasis. However, the involvement of the PINK1/Parkin signaling pathway, a classical regulatory route for mitophagy, in the protective effects of MH against IR remains unclear. To investigate this phenomenon, we used neuron-like SH-SY5Y cells and employed an oxygen-glucose deprivation/reoxygenation (OGD/R) model to simulate the in vitro IR process, and conducted a series of cell experiments. Our results demonstrated that under MH conditions, the expression levels of PINK1 and Parkin were upregulated after 5 h of ischemia-hypoxia followed by 24 h of reoxygenation, and the protective effect on cells was also significant. Furthermore, the inhibition of the mitophagy pathway may partially eliminate the protective effect provided by MH against OGD/R-induced damage.These findings indicate that the protective effects of MH against IR is mediated, at least in part, through the PINK1/Parkin-dependent mitophagy pathway.This study provides new insights into the mechanisms by which MH mitigates IR injury and may offer potential therapeutic targets for treating IR-related diseases.

Indexed as

Hypothermia, InducedMitophagyProtein KinasesReperfusion InjuryUbiquitin-Protein LigasesCell Line, TumorGlucoseHumansNeuronsPTEN-Induced Putative KinaseSignal TransductionGlucoseparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesIschemia-reperfusion injuryMild hypothermiaMitophagyOxygen-glucose deprivationParkinPINK1

Identifiers

PMID42690277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.